Caffeine may lower Parkinson's Risk: Study

In a study presented at the American Academy of Neurology 64th Annual Meeting in New Orleans, Dr. G. Webster Ross and colleagues report a relationship between coffee and caffeine consumption and a reduced potential for Parkinson’s disease. Specifically, drinking three large cups of coffee a day—a total of approximately 28 ounces over the course of 24 hours—could protect against the development of Lewy bodies in the brain.

These abnormal accumulations of protein within nerve cells are an established precursor—in other words, the earliest, preclinical stage of Parkinson’s. Earlier work published by Dr. Ross and colleagues that looked at the incidence of Parkinson’s over 30 years of follow-up among also showed that it’s occurrence was highest among those who never drank coffee and lowest among those who consumed the most, with a similar trend for total caffeine intake.

In order to identify Lewy bodies in subjects, researchers used sensitive alpha-synuclein staining in multiple brain stem regions of the 519 participants and performed Braak PD staging. Of the 519 participants, it was established that 443 had no Lewy bodies present, whereas 76 did.

The exact protective mechanism of caffeine in regard to the brain is unknown, but animal studies do indicate that caffeine blocks the adenosine A2A receptors that control movement, which are very sensitive to caffeine. Animal research has also shown a protective effect of genetic depletion of the A2A receptor in knockout models of the gene, said Dr. Ross.

For humans, this explanation is still unconfirmed. “Whether coffee or caffeine are neuroprotective in humans remains uncertain,” said Dr. Ross. “There’s still this sort of nagging idea that people with PD may for some reason avoid coffee and caffeine containing products.”

Nonetheless, this study does establish an encouraging, positive correlation for those looking to maintain neurological health and function. Along with recently reported antioxidant properties, evidence is growing in favor of coffee and the caffeine it contains, in terms of potential health benefits.